August 2024
Publication Release: Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression.
Publication Release: Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer’s Disease.
June 2024
Publication Release: Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.
May 2024
Publication Release: Novel off-Targeting Events Identified after Genome Wide Analysis of CRISPR-Cas Edited Pigs.
April 2022
Publication Release: Chloride channel accessory 1 (CLCA1) gene deficiency causes selective loss of mucus production in a new pig model.
March 2022
Publication Release: Disruption of Anthrax Toxin Receptor 1 in Pigs Leads to a Rare Disease Phenotype and Protection From Senecavirus A Infection.
Publication Release: Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa.
Swine in Biomedical Research Conference
Register Now! : Swine in Biomedical Research Conference 2022
November 2021
Publication Release: Serologic titers to Leptospira in vaccinated pigs and interpretation for surveillance.
October 2021
Publication Release: Challenges and Considerations During In Vitro Production of Porcine Embryos.
September 2021
New Strain Available: CLCA1 KO
August 2021
Publication Release: Effects of RAD51-Stimulatory Compound 1 (RS-1) and Its Vehicle, DMSO, on Pig Embryo Culture.
July 2021
Publication Release: Cardiovascular Development and Congenital Heart Disease Modeling in the Pig.
Publication Release: Limited Expansion of Human Hepatocytes in FAH/RAG2-Deficient Swine.
October 2020
Publication Release: A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing.
July 2020
Publication Release: A novel swine sex-linked marker and its application across different mammalian species.
June 2020
Publication Release: Chemical simulation of hypoxia in donor cells improves development of somatic cell nuclear transfer‐derived embryos and increases abundance of transcripts related to glycolysis
December 2019
News Article: China and the US Are Racing to Create a Super Pig
January 2019
Read the updates on the production of xenotransplantation swine models.
December 2018
Two new models were born this at the NSRRC including the CLCA1-/- pigs and transgenic pigs TIE2 promoter driving HSPA5
November 2018
NSRRC representatives, Dr. Wells and Dr. Whitworth, participate in the Immunobiology of Xenotransplantation consortium meeting at NIH, Rockville, MD
August 2018
National Swine Resource and Research Center receives renewed funding for an additional 5 years.
https://www.nationalhogfarmer.com/agenda/university-missouri-receives-7-million-swine-model-research
March 2018
Single step production of Cas9 mRNA for zygote injection. An inexpensive and easy way to make highly stable Cas9 mRNA. Redel et al 2018 Biotechniques 64:118-12
Redel et al. 2018 Biotechniques
April 2017
Conference Announcements
14th Congress Advancing Xenotransplantation Science Worldwide
6th Swine in Biomedical Research Conference
November 1, 2016
October 1, 2016
Publication release
Suggested Guidelines for Tissue Collection
August 1, 2016
Publication release
Birth of potential new model: PAH KO
Donation of a new model: Dr. Monique Lorson, MU donates SMN -/+ animals
February 2016
Publication release
Birth of two potential new models
COL6A
