11 2 Multi xeno pig

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Swine are the optimal model species for investigation of a large number of human diseases and have made valuable contributions to almost every field of human medicine. Swine share anatomic and physiologic characteristics with humans that make them ideal models for research. In addition, the anatomy and physiology make pig organs likely candidates for xenotransplantation.

The National Swine Resource and Research Center (NSRRC) was established in 2003 to develop the infrastructure to ensure that biomedical investigators across a variety of disciplines have access to critically needed swine models of human health and disease. The NSRRC will also serve as a central resource for reagents, creation of new genetically modified swine, and information and training related to use of swine models in biomedical research.

Questions, comments, feedback? Contact the NSRRC at NSRRC@missouri.edu.

National Swine Resource and Research Center is pleased to be a part of the Resource Identification Initiative, a project aimed at clearly identifying key research resources used in the course of scientific research. These key research resources include model organisms, antibodies and software tools. All citations for the pig stored in NSRRC can now also be found at http://scicrunch.org/resources, a portal where publishers (see list of participating journals) are directing authors during the publication process, usually at the acceptance of the publication. Authors are asked to paste the ‘cite this’ text in the methods section for each organism, antibody and software tool used in the course of research, a step that helps to disambiguate the organisms used in research and allow for straightforward aggregation of data around key resources, thereby questions such as “who else used this pig?” will be answered more easily. The format for citation is relatively straightforward, and we provide a couple of examples below:

  • Genetically modified organisms: “Pigs used in this study were GGTA1 knockout with the addition of hDAF, (RRID:NSRRC:0009).”
  • Antibodies: “Sections were stained with a rabbit polyclonal antibody against ERK1 (Abgent Cat# AP7251E, RRID:AB_2140114).”
  • Software tools: “…terminals were mapped with a computer-assisted mapping program (Neurolucida, v10, RRID:SCR_001775).”

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The NSRRC is funded by the following NIH Institutes; Division of Comparative Medicine, Division of Program Coordination, Planning, and Strategic Initatives, Office of Research Infrastructure Programs (ORIP), Office of the Director, and NIAID and NHLBI.