A knockout of the TMPRSS2 gene
Donated by the National Swine Resource and Research Center, University of Missouri.
Reference:
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Kwon T, Artiaga BL, McDowell CD, Whitworth KM, Wells KD, Prather RS, Delhon G, Cigan M, White SN, Retallick J, Gaudreault NN, Morozov I, Richt JA. Gene editing of pigs to control influenza A virus infections. Emerg Microbes Infect. 2024 Dec;13(1):2387449. doi: 10.1080/22221751.2024.2387449. Epub 2024 Aug 24. PMID: 39083026; PMCID: PMC11346336.
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Ciacci Zanella G, Snyder CA, Arruda BL, Whitworth K, Green E, Poonooru RR, Telugu BP, Baker AL. Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus. Front Genome Ed. 2024 May 31;5:1320180. doi: 10.3389/fgeed.2023.1320180. PMID: 38883409; PMCID: PMC11176495.
- Whitworth KM, Benne JA, Spate LD, Murphy SL, Samuel MS, Murphy CN, Richt JA, Walters E, Prather RS, Wells KD. 2017. Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs. Transgenic Res. 2017 Feb;26(1):97-107. doi: 10.1007/s11248-016-9989-6. Epub 2016 Oct 15. PMCID: PMC5247313.