NSRRC:0071 CD163

Knockout of gene function via zygote injection of the CRISPR Cas-9 system. Homozygous and heterozygous available.

Publications:

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus

Genetic engineering alveolar macrophages for host resistance to PRRSV

Gene editing as applied to prevention of reproductive porcine reproductive and respiratory syndrome

Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)