A porcine model for Phenylketonuria (PKU) was successfully established via early zygote injection of the CRISPR/Cas9 system targeting exon 6 of the PAH gene.
Further information can be found in our publication: Koppes EA, Redel BK, Johnson MA, et al. A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing. JCI Insight. 2020;5(20):e141523. Published 2020 Oct 15. doi:10.1172/jci.insight.141523